Hepatocyte growth factor, hepatocyte growth factor activator and arginine in a rat fulminant colitis model

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Hepatocyte growth factor, hepatocyte growth factor activator and arginine in a rat fulminant colitis model.

INTRODUCTION Dextran sodium sulfate (DSS) is commonly used to induce a murine fulminant colitis model. Hepatocyte growth factor (HGF) has been shown to decrease the symptoms of inflammatory bowel disease (IBD) but the effect of its activator, HGFA, is not well characterized. Arginine reduces effects of oxidative stress but its effect on IBD is not well known. The primary aim is to determine whe...

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Background and Objective: Epilepsy as a chronic neurological disorder causes inherent seizures and learning and memory failure. Since there is no acceptable control of seizures in some patients with the current recommended drug therapy, new medications with different mechanisms of action are needed. Here, the beneficial effect of hepatocyte growth factor (HGF) was evaluated in an experimental m...

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Hepatocyte Growth Factor

Hepatocyte growth factor (HGF) exerts biological activity through the Met receptor tyrosine kinase. HGF plays essential roles in the embryonic development of the liver and placenta, and in the migration of myogenic precursor cells. In mature tissues, HGF plays roles in tissue protection and regeneration, including in the liver and kidney. HGF participates in invasion, metastasis, and drug resis...

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Hepatocyte growth factor and hepatocyte growth factor receptor in the lacrimal gland, tears, and cornea.

PURPOSE The purpose of this study was to characterize the expression of hepatocyte growth factor (HGF) and HGF receptor proteins in lacrimal gland, tears, and cornea. METHODS The reverse transcription-polymerase chain reaction method was used to detect HGF and HGF receptor messenger RNA in human lacrimal gland tissue. HGF and HGF (c-met) receptor monoclonal antibody specificity was demonstrat...

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Hepatocyte growth factor and the hepatocyte growth factor receptor signalling complex as targets in cancer therapies

Since its discovery in the late 1980s 1,2, hepatocyte growth factor (HGF) has been under intense investigation for its role in cancer. Hepatocyte growth factor has been established as a mitogen that regulates cell growth and death, a motogen that stimulates cell motility, a morphogen that modulates cell morphology and tissue or organ regeneration, and an angiogenic factor that induces angiogene...

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ژورنال

عنوان ژورنال: Annals of Medicine and Surgery

سال: 2016

ISSN: 2049-0801

DOI: 10.1016/j.amsu.2016.03.039